منابع مشابه
Life without complex I: proteome analyses of an Arabidopsis mutant lacking the mitochondrial NADH dehydrogenase complex
The mitochondrial NADH dehydrogenase complex (complex I) is of particular importance for the respiratory chain in mitochondria. It is the major electron entry site for the mitochondrial electron transport chain (mETC) and therefore of great significance for mitochondrial ATP generation. We recently described an Arabidopsis thaliana double-mutant lacking the genes encoding the carbonic anhydrase...
متن کاملMitochondrial respiration without ubiquinone biosynthesis.
Ubiquinone (UQ), a.k.a. coenzyme Q, is a redox-active lipid that participates in several cellular processes, in particular mitochondrial electron transport. Primary UQ deficiency is a rare but severely debilitating condition. Mclk1 (a.k.a. Coq7) encodes a conserved mitochondrial enzyme that is necessary for UQ biosynthesis. We engineered conditional Mclk1 knockout models to study pathogenic eff...
متن کاملContinuous Respiration without Respiratory Movements
The object of the function of respiration is to supply the animal with oxygen and to remove carbon dioxide. To attain this object the vertebrates are provided with a complicated mechanism of which the respiratory movements are an essential feature. The respiration appears as a continuous chain of rhythmically recurring cycles, each cycle consisting of two antagonistic movements, one which carri...
متن کاملDimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
We report here a new mitochondrial regulation occurring only in intact cells. We have investigated the effects of dimethylbiguanide on isolated rat hepatocytes, permeabilized hepatocytes, and isolated liver mitochondria. Addition of dimethylbiguanide decreased oxygen consumption and mitochondrial membrane potential only in intact cells but not in permeabilized hepatocytes or isolated mitochondr...
متن کاملThe diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration
OBJECTIVE The sodium-glucose transporter 2 (SGLT2) inhibitors Canagliflozin and Dapagliflozin are recently approved medications for type 2 diabetes. Recent studies indicate that SGLT2 inhibitors may inhibit the growth of some cancer cells but the mechanism(s) remain unclear. METHODS Cellular proliferation and clonogenic survival were used to assess the sensitivity of prostate and lung cancer ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2018
ISSN: 0960-9822
DOI: 10.1016/j.cub.2018.04.030